Image myImage = new Bitmap(300, 200); Graphics g = Graphics.FromImage(myImage); g.CopyFromScreen(new Point(Cursor.Position.X - 150, Cursor.Position.Y - 25), new Point(0, 0), new Size(300, 200)); IntPtr dc1 = g.GetHdc(); g.ReleaseHdc(dc1); this.pictureBox1.Image = myImage; myImage.Save("c:\\1.jpeg");